InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CRHR1

Summary

InnateDB Protein

IDBP-693663.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRHR1

Protein Name

corticotropin-releasing factor receptor 1

Synonyms

CRFR1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003567

InnateDB Gene

IDBG-641310 (CRHR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015056	corticotrophin-releasing factor receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0030325	adrenal gland development
GO:0042596	fear response
GO:0048149	behavioral response to ethanol
GO:0051458	corticotropin secretion
GO:0051867	general adaptation syndrome, behavioral process
GO:0071376	cellular response to corticotropin-releasing hormone stimulus
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002001 GPCR, family 2, diuretic hormone receptor
IPR003051 GPCR, family 2, corticotropin releasing factor receptor
IPR003052 GPCR, family 2, corticotropin releasing factor receptor, type 1
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01127
PR01279
PR01280

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MCX2

UniProt Splice Variant

Entrez Gene

281716

UniGene

RefSeq

NP_776712

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02049283 DAAA02049284

GenPept