InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAPT

Summary

InnateDB Protein

IDBP-693686.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPT

Protein Name

Microtubule-associated protein tau

Synonyms

tau;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000054412

InnateDB Gene

IDBG-641321 (MAPT)

Protein Structure

UniProt Annotation

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Disease Associations

Tissue Specificity

Expressed in neurons.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0017124	SH3 domain binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0034185	apolipoprotein binding
GO:0071813	lipoprotein particle binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001764	neuron migration
GO:0007409	axonogenesis
GO:0007628	adult walking behavior
GO:0008088	axon cargo transport
GO:0010506	regulation of autophagy
GO:0031116	positive regulation of microtubule polymerization
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0060632	regulation of microtubule-based movement

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005930	axoneme
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0034399	nuclear periphery
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0042995	cell projection
GO:0045298	tubulin complex

Protein Structure and Domains

PDB ID

InterPro

IPR001084 Microtubule associated protein, tubulin-binding repeat
IPR002955 Microtubule-associated protein Tau

PFAM

PF00418

PRINTS

PR01261

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29172

PhosphoSite

PhosphoSite-P29172

TrEMBL

UniProt Splice Variant

Entrez Gene

281296

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC109941 L34940 L34941 L34942 L34943 L34944 L34946 L34947 L34948 L34949 L34950 L34951 L34952 L34953 M26157 M26158 M26178

GenPept

AAA30770 AAA30771 AAA51601 AAA51602 AAA51603 AAA51604 AAA51605 AAA51606 AAA51609 AAI09942