Bos taurus Gene: MAPT
Summary
InnateDB Gene IDBG-641321.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPT
Gene Name Microtubule-associated protein tau
Synonyms tau;
Species Bos taurus
Ensembl Gene ENSBTAG00000017512
Encoded Proteins
Microtubule-associated protein tau
Microtubule-associated protein tau
Microtubule-associated protein tau
Microtubule-associated protein tau
Microtubule-associated protein tau
Microtubule-associated protein tau
Microtubule-associated protein tau
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186868:
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer\'s disease, Pick\'s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46524375-46644713
Strand Forward strand
Band
Transcripts
ENSBTAT00000064492 ENSBTAP00000054412
ENSBTAT00000065660 ENSBTAP00000056547
ENSBTAT00000023284 ENSBTAP00000023284
ENSBTAT00000064966 ENSBTAP00000054994
ENSBTAT00000065509 ENSBTAP00000056351
ENSBTAT00000042687 ENSBTAP00000040320
ENSBTAT00000065483 ENSBTAP00000056106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 61 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0034185 apolipoprotein binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0007409 axonogenesis
GO:0007628 adult walking behavior
GO:0008088 axon cargo transport
GO:0010506 regulation of autophagy
GO:0031116 positive regulation of microtubule polymerization
GO:0032387 negative regulation of intracellular transport
GO:0045773 positive regulation of axon extension
GO:0047497 mitochondrion transport along microtubule
GO:0048675 axon extension
GO:0060632 regulation of microtubule-based movement
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0034399 nuclear periphery
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042995 cell projection
GO:0045298 tubulin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
Apoptosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL6 pathway
Leptin pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
KEGG
MAPK signaling pathway pathway
Alzheimer's disease pathway
MAPK signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
LPA receptor mediated events
Reelin signaling pathway
Signaling mediated by p38-gamma and p38-delta
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_174106
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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