Version 5.4
Bos taurus Protein: ASIP
Summary
InnateDB Protein IDBP-694286.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIP
Protein Name Agouti-signaling protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045382
InnateDB Gene IDBG-641881 (ASIP)
Protein Structure
UniProt Annotation
Function Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0031779 melanocortin receptor binding
GO:0031781 type 3 melanocortin receptor binding
GO:0031782 type 4 melanocortin receptor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0008343 adult feeding behavior
GO:0009755 hormone-mediated signaling pathway
GO:0032402 melanosome transport
GO:0032438 melanosome organization
GO:0040030 regulation of molecular function, epigenetic
GO:0042438 melanin biosynthetic process
GO:0043473 pigmentation
GO:0071514 genetic imprinting
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR007733 Agouti
IPR027300 Agouti domain
PFAM PF05039
PRINTS
PIRSF
SMART SM00792
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29414
PhosphoSite PhosphoSite-
TrEMBL Q06W02
UniProt Splice Variant
Entrez Gene 404192
UniGene Bt.89130
RefSeq NP_996674
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY348953 AY348954 AY352659 BC102291 DQ494381 X99691 X99692
GenPept AAI02292 AAQ56605 ABF50192 CAA68003 CAA68004

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca