Version 5.4
Bos taurus Protein: TNNI3
Summary
InnateDB Protein IDBP-694333.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNI3
Protein Name Troponin I, cardiac muscle
Synonyms TNNI3;
Species Bos taurus
Ensembl Protein ENSBTAP00000008425
InnateDB Gene IDBG-641923 (TNNI3)
Protein Structure
UniProt Annotation
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019855 calcium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030172 troponin C binding
GO:0031014 troponin T binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001570 vasculogenesis
GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions
GO:0006874 cellular calcium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0006941 striated muscle contraction
GO:0007507 heart development
GO:0032780 negative regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060047 heart contraction
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005861 troponin complex
Protein Structure and Domains
PDB ID
InterPro IPR001978 Troponin
IPR021666 Troponin I residues 1-32
PFAM PF00992
PF11636
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P08057
PhosphoSite PhosphoSite-P08057
TrEMBL
UniProt Splice Variant
Entrez Gene 511094
UniGene Bt.11438
RefSeq NP_001035607
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ842179
GenPept CAH57016

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca