InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TNNI3

Summary

InnateDB Gene

IDBG-641923.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNI3

Gene Name

Troponin I, cardiac muscle

Synonyms

TNNI3

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006424

Encoded Proteins

IDBP-694333

Troponin I, cardiac muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000129991:
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:62717575-62721350

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008425

ENSBTAP00000008425

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0030172	troponin C binding
GO:0031014	troponin T binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0001980	regulation of systemic arterial blood pressure by ischemic conditions
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006941	striated muscle contraction
GO:0007507	heart development
GO:0032780	negative regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060047	heart contraction
GO:0060048	cardiac muscle contraction