InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SIRT3

Summary

InnateDB Protein

IDBP-694349.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT3

Protein Name

sirtuin 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002648

InnateDB Gene

IDBG-641924 (SIRT3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006476	protein deacetylation
GO:0009060	aerobic respiration
GO:0034983	peptidyl-lysine deacetylation
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003000 Sirtuin family
IPR017328 Sirtuin, class I
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

PIRSF037938

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

G5E521

UniProt Splice Variant

Entrez Gene

614027

UniGene

Bt.56046

RefSeq

NP_001193598

HUGO

HGNC:14931

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02032476

GenPept