Version 5.4
Bos taurus Protein: AP1M1
Summary
InnateDB Protein IDBP-694759.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1M1
Protein Name AP-1 complex subunit mu-1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017724
InnateDB Gene IDBG-642302 (AP1M1)
Protein Structure
UniProt Annotation
Function Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. {ECO:0000250UniProtKB:Q9BXS5, ECO:0000269PubMed:12604586}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032438 melanosome organization
GO:0035646 endosome to melanosome transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030131 clathrin adaptor complex
GO:0030665 clathrin-coated vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001392 Clathrin adaptor, mu subunit
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR022775 AP complex, mu/sigma subunit
IPR028565 Mu homology domain
PFAM PF00928
PF01217
PRINTS PR00314
PIRSF PIRSF005992
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ81
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504310
UniGene Bt.23352
RefSeq NP_001039349
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105477
GenPept AAI05478

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca