Version 5.4
Bos taurus Protein: P4HB
Summary
InnateDB Protein IDBP-694832.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HB
Protein Name protein disulfide-isomerase precursor
Synonyms PDI;
Species Bos taurus
Ensembl Protein ENSBTAP00000007943
InnateDB Gene IDBG-642374 (P4HB)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0004656 procollagen-proline 4-dioxygenase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0031545 peptidyl-proline 4-dioxygenase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006457 protein folding
GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0034976 response to endoplasmic reticulum stress
GO:0045454 cell redox homeostasis
GO:0071456 cellular response to hypoxia
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016222 procollagen-proline 4-dioxygenase complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005788 Disulphide isomerase
IPR005792 Protein disulphide isomerase
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G9BHW9
UniProt Splice Variant
Entrez Gene 281373
UniGene Bt.74705
RefSeq NP_776560
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146271 BT030719 DAAA02049418 HQ585571
GenPept AAI46272 ABS45035 AEA11467

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca