InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.61976

Summary

InnateDB Protein

IDBP-695023.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.61976

Protein Name

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011767

InnateDB Gene

IDBG-642561 (BT.61976)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 359 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	359 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019904	protein domain specific binding
GO:0020037	heme binding
GO:0042169	SH2 domain binding
GO:0044325	ion channel binding
GO:0046875	ephrin receptor binding
GO:0051219	phosphoprotein binding
GO:0070851	growth factor receptor binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030900	forebrain development
GO:0032463	negative regulation of protein homooligomerization
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393	regulation of protein binding
GO:0046777	protein autophosphorylation
GO:0048477	oogenesis
GO:0051897	positive regulation of protein kinase B signaling
GO:0051902	negative regulation of mitochondrial depolarization
GO:0060065	uterus development
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0070555	response to interleukin-1
GO:0071803	positive regulation of podosome assembly
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000811	negative regulation of anoikis
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM