InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HOP

Summary

InnateDB Protein

IDBP-695051.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOP

Protein Name

Homeodomain-only protein

Synonyms

HOP; LAGY;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003013

InnateDB Gene

IDBG-642587 (HOP)

Protein Structure

UniProt Annotation

Function

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001829	trophectodermal cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007507	heart development
GO:0008016	regulation of heart contraction
GO:0016575	histone deacetylation
GO:0043393	regulation of protein binding
GO:0043415	positive regulation of skeletal muscle tissue regeneration
GO:0045596	negative regulation of cell differentiation
GO:0048286	lung alveolus development
GO:0051155	positive regulation of striated muscle cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like

PFAM

PF00046

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8MJD5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281270

UniGene

RefSeq

NP_776522

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF492683 BC102635

GenPept

AAI02636 AAM46835