Bos taurus Protein: BPI | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-695060.2 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | BPI | ||||||||||
Protein Name | Bactericidal permeability-increasing protein | ||||||||||
Synonyms | |||||||||||
Species | Bos taurus | ||||||||||
Ensembl Protein | ENSBTAP00000018669 | ||||||||||
InnateDB Gene | IDBG-642592 (BPI) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. | ||||||||||
Subcellular Localization | Secreted {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Restricted to cells of the myeloid series. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR001124
Lipid-binding serum glycoprotein, C-terminal IPR017942 Lipid-binding serum glycoprotein, N-terminal IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain |
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PFAM |
PF02886
PF01273 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00329
SM00328 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P17453 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | F1MQ17 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 280734 | ||||||||||
UniGene | Bt.103 | ||||||||||
RefSeq | NP_776320 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | |||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | BC102310 DAAA02036561 DAAA02036562 X52563 | ||||||||||
GenPept | AAI02311 CAA36797 | ||||||||||