Bos taurus Protein: RDH8
Summary
InnateDB Protein IDBP-695680.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDH8
Protein Name Retinol dehydrogenase 8
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013443
InnateDB Gene IDBG-643148 (RDH8)
Protein Structure
UniProt Annotation
Function Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. {ECO:0000269PubMed:10753906}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in photoreceptor outer segments in the retina (at protein level). {ECO:0000269PubMed:10753906}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0006703 estrogen biosynthetic process
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0050896 response to stimulus
GO:0055114 oxidation-reduction process
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR011348 17beta-dehydrogenase
IPR013968 Polyketide synthase, KR
IPR020842 Polyketide synthase/Fatty acid synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PR01397
PIRSF PIRSF000126
PIRSF000095
SMART SM00822
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9N126
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281449
UniGene Bt.266
RefSeq NP_776592
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF229846
GenPept AAF63161