Version 5.4
Bos taurus Protein: PTPN1
Summary
InnateDB Protein IDBP-695758.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN1
Protein Name tyrosine-protein phosphatase non-receptor type 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008678
InnateDB Gene IDBG-643215 (PTPN1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030971 receptor tyrosine kinase binding
GO:0044822 poly(A) RNA binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008286 insulin receptor signaling pathway
GO:0009966 regulation of signal transduction
GO:0016311 dephosphorylation
GO:0030100 regulation of endocytosis
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031532 actin cytoskeleton reorganization
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
Cellular Component
GO:0005769 early endosome
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0097443 sorting endosome
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PRINTS PR00700
PIRSF PIRSF000926
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QQN2
UniProt Splice Variant
Entrez Gene 508658
UniGene Bt.9542
RefSeq NP_001093796
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149916 DAAA02036854
GenPept AAI49917

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca