InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE4A

Summary

InnateDB Protein

IDBP-695834.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4A

Protein Name

phosphodiesterase 4A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015961

InnateDB Gene

IDBG-643271 (PDE4A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0008152	metabolic process
GO:0010738	regulation of protein kinase A signaling
GO:0035690	cellular response to drug
GO:0043949	regulation of cAMP-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MBI5

UniProt Splice Variant

Entrez Gene

512222

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02019463 DAAA02019464

GenPept