InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SUMO1

Summary

InnateDB Protein

IDBP-695849.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUMO1

Protein Name

Small ubiquitin-related modifier 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013000

InnateDB Gene

IDBG-643297 (SUMO1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Recruited by BCL11A into the nuclear body. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 652 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	652 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0030578	PML body organization
GO:0060021	palate development
GO:0090204	protein localization to nuclear pore

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000626 Ubiquitin-like
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00240
PF14560
PF11976

PRINTS

PIRSF

SMART

SM00213

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9D1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

614967

UniGene

RefSeq

NP_001030535

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102884 BT020989

GenPept

AAI02885 AAX09006