Version 5.4
Bos taurus Gene: SUMO1
Summary
InnateDB Gene IDBG-643297.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUMO1
Gene Name Small ubiquitin-related modifier 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009859
Encoded Proteins
IDBP-695849
Small ubiquitin-related modifier 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116030:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:91155252-91180862
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013000 ENSBTAP00000013000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 652 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 652 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019789 SUMO ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0030578 PML body organization
GO:0060021 palate development
GO:0090204 protein localization to nuclear pore
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016604 nuclear body
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000116030
View Gene Order
ENSMUSG00000026021
View Gene Order
Pathways
NETPATH
REACTOME
REACT_208746
SUMO is proteolytically processed pathway
REACT_204778
SUMOylation pathway
REACT_224743
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
REACT_213612
Cytokine Signaling in Immune system pathway
REACT_212455
Interferon gamma signaling pathway
REACT_213138
Immune System pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_225103
Interferon Signaling pathway
REACT_224754
Regulation of IFNG signaling pathway
REACT_211677
SUMO is conjugated to E1 (UBA2:SAE1) pathway
REACT_211390
Processing and activation of SUMO pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_24980
Regulation of IFNG signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_22161
Post-translational protein modification pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_163793
Processing and activation of SUMO pathway
REACT_25229
Interferon Signaling pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_163646
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
REACT_163812
SUMO is conjugated to E1 (UBA2:SAE1) pathway
REACT_163725
SUMO is proteolytically processed pathway
REACT_163823
SUMOylation pathway
REACT_196647
SUMO is conjugated to E1 (UBA2:SAE1) pathway
REACT_196649
SUMO is proteolytically processed pathway
REACT_196652
SUMOylation pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_198645
Regulation of IFNG signaling pathway
REACT_223195
SUMO is transferred from E1 to E2 (UBE2I, UBC9) pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_196651
Processing and activation of SUMO pathway
KEGG
hsa03013
RNA transport pathway
mmu03013
RNA transport pathway
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
hdac_classii_pathway
Signaling events mediated by HDAC Class II
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
Cross-References
SwissProt Q5E9D1
TrEMBL
UniProt Splice Variant
Entrez Gene 614967
UniGene
RefSeq NM_001035458 XM_005192407 XM_005211634 XM_005211635
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102884 BT020989
GenPept AAI02885 AAX09006
RNA Seq Atlas 101906855 614967

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca