Version 5.4
Bos taurus Protein: IDH1
Summary
InnateDB Protein IDBP-696074.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IDH1
Protein Name isocitrate dehydrogenase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027348
InnateDB Gene IDBG-643516 (IDH1)
Protein Structure
UniProt Annotation
Function May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency. {ECO:0000269PubMed:10358094}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed preferentially in corneal epithelium. Constitute approximately 13% of the total soluble bovine corneal epithelial proteins. {ECO:0000269PubMed:10358094}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005102 receptor binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006749 glutathione metabolic process
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004790 Isocitrate dehydrogenase NADP-dependent
IPR024084 Isopropylmalate dehydrogenase-like domain
PFAM PF00180
PRINTS
PIRSF PIRSF000108
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9XSG3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281235
UniGene Bt.97013
RefSeq NP_851355
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF136009 BC103368
GenPept AAD34457 AAI03369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca