InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FADS2

Summary

InnateDB Protein

IDBP-696092.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FADS2

Protein Name

Fatty acid desaturase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020610

InnateDB Gene

IDBG-643533 (FADS2)

Protein Structure

UniProt Annotation

Function

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and as well other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004768	stearoyl-CoA 9-desaturase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037	heme binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0006636	unsaturated fatty acid biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR001715 Calponin homology domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

PFAM

PF00173
PF00307
PF00487

PRINTS

PR00363

PIRSF

PIRSF015921

SMART

SM00033

TIGRFAMs

Post-translational Modifications

Modification

Cross-References