Version 5.4
Bos taurus Gene: FADS2
Summary
InnateDB Gene IDBG-643533.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FADS2
Gene Name Fatty acid desaturase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015505
Encoded Proteins
IDBP-696092
Fatty acid desaturase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134824:
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:41045232-41082248
Strand Forward strand
Band
Transcripts
ENSBTAT00000020610 ENSBTAP00000020610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0020037 heme binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006636 unsaturated fatty acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134824
View Gene Order
ENSMUSG00000024665
View Gene Order
Pathways
NETPATH
REACTOME
REACT_203420
Linoleic acid (LA) metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_224207
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
REACT_212938
alpha-linolenic acid (ALA) metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121100
Linoleic acid (LA) metabolism pathway
REACT_121147
alpha-linolenic acid (ALA) metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121284
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_196541
alpha-linolenic acid (ALA) metabolism pathway
REACT_196530
Linoleic acid (LA) metabolism pathway
REACT_196529
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa01040
Biosynthesis of unsaturated fatty acids pathway
hsa03320
PPAR signaling pathway pathway
mmu01040
Biosynthesis of unsaturated fatty acids pathway
mmu03320
PPAR signaling pathway pathway
mmu00592
alpha-Linolenic acid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt A4FV48
TrEMBL J7M8T5 J7M8U1 J7MH61
UniProt Splice Variant
Entrez Gene 521822
UniGene Bt.3891
RefSeq NM_001083444 XM_005226929
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB669302 AB669303 AB669304 AB669305 AB669306 AB669307 AB669308 AB669309 AB669310 AB669313 AB669314 AB669315 AB669316 AB669317 AB669318 AB669319 AB669320 AB669328 AB669329 AB669330 AB669331 AB669332 AB669333 AB669334 AB669335 AB669336 AB669337 BC123735
GenPept AAI23736 BAM42535 BAM42536 BAM42537 BAM42538 BAM42539 BAM42540 BAM42541 BAM42542 BAM42543 BAM42546 BAM42547 BAM42548 BAM42549 BAM42550 BAM42551 BAM42552 BAM42553 BAM42561 BAM42562 BAM42563 BAM42564 BAM42565 BAM42566 BAM42567 BAM42568 BAM42569 BAM42570
RNA Seq Atlas 521822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca