Version 5.4
Bos taurus Protein: ECSIT
Summary
InnateDB Protein IDBP-696131.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECSIT
Protein Name Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020029
InnateDB Gene IDBG-643570 (ECSIT)
Protein Structure
UniProt Annotation
Function Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250}.Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0001707 mesoderm formation
GO:0002376 immune system process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response
GO:0051341 regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR010418 ECSIT
PFAM PF06239
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SX05
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507245
UniGene Bt.2894
RefSeq NP_001029458
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104572
GenPept AAI04573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca