InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AXIN2

Summary

InnateDB Protein

IDBP-696303.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AXIN2

Protein Name

axin 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000040177

InnateDB Gene

IDBG-643724 (AXIN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0070411	I-SMAD binding

Biological Process

GO:0001756	somitogenesis
GO:0001934	positive regulation of protein phosphorylation
GO:0001957	intramembranous ossification
GO:0003139	secondary heart field specification
GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010942	positive regulation of cell death
GO:0030111	regulation of Wnt signaling pathway
GO:0030282	bone mineralization
GO:0032423	regulation of mismatch repair
GO:0034613	cellular protein localization
GO:0035414	negative regulation of catenin import into nucleus
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0042476	odontogenesis
GO:0043570	maintenance of DNA repeat elements
GO:0045668	negative regulation of osteoblast differentiation
GO:0048255	mRNA stabilization
GO:0061181	regulation of chondrocyte development
GO:0070602	regulation of centromeric sister chromatid cohesion
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001158 DIX domain
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00778
PF08833

PRINTS

PR01301

PIRSF

SMART

SM00021
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt