InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MARK2

Summary

InnateDB Protein

IDBP-696442.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARK2

Protein Name

serine/threonine-protein kinase MARK2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013818

InnateDB Gene

IDBG-643848 (MARK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.

Predicted by orthology
Total	57 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0030010	establishment of cell polarity
GO:0035556	intracellular signal transduction
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0050770	regulation of axonogenesis

Cellular Component

GO:0005634	nucleus
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0045180	basal cortex
GO:0097427	microtubule bundle

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001772 Kinase associated domain 1 (KA1)
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028375 KA1 domain/Ssp2 C-terminal domain

PFAM

PF00069
PF07714
PF02149

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A6QNL2

UniProt Splice Variant

Entrez Gene

535197

UniGene

Bt.26432

RefSeq

NP_001095652

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148882 DAAA02063507 DAAA02063508 DAAA02063509

GenPept

AAI48883