Version 5.4
Bos taurus Gene: MARK2
Summary
InnateDB Gene IDBG-643848.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARK2
Gene Name serine/threonine-protein kinase MARK2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007825
Encoded Proteins
IDBP-696442
serine/threonine-protein kinase MARK2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072518:
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:42829261-42865910
Strand Forward strand
Band
Transcripts
ENSBTAT00000013818 ENSBTAP00000013818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0030010 establishment of cell polarity
GO:0035556 intracellular signal transduction
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005634 nucleus
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0045180 basal cortex
GO:0097427 microtubule bundle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072518
View Gene Order
ENSMUSG00000024969
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL A6QNL2
UniProt Splice Variant
Entrez Gene 535197
UniGene Bt.26432
RefSeq NM_001102182 XM_005227126
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148882 DAAA02063507 DAAA02063508 DAAA02063509
GenPept AAI48883
RNA Seq Atlas 535197

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca