InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RPS6KA4

Summary

InnateDB Protein

IDBP-696539.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA4

Protein Name

ribosomal protein S6 kinase, 90kDa, polypeptide 4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020910

InnateDB Gene

IDBG-643940 (RPS6KA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0016310	phosphorylation
GO:0033129	positive regulation of histone phosphorylation
GO:0035066	positive regulation of histone acetylation
GO:0035556	intracellular signal transduction
GO:0043987	histone H3-S10 phosphorylation
GO:0043988	histone H3-S28 phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR010440 Lipopolysaccharide kinase
IPR011009 Protein kinase-like domain
IPR016239 Ribosomal protein S6 kinase II
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF06293
PF00433

PRINTS

PR00109

PIRSF

PIRSF000606

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References