InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RPS6KA4

Summary

InnateDB Gene

IDBG-643940.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA4

Gene Name

ribosomal protein S6 kinase alpha-4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039153

Encoded Proteins

IDBP-696539

ribosomal protein S6 kinase, 90kDa, polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18690222

[Homo sapiens] Negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL-10 and DUSP1 promoters

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162302:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 29:43267468-43281242

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020910

ENSBTAP00000020910

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0009103	lipopolysaccharide biosynthetic process
GO:0016310	phosphorylation
GO:0033129	positive regulation of histone phosphorylation
GO:0035066	positive regulation of histone acetylation
GO:0035556	intracellular signal transduction
GO:0043987	histone H3-S10 phosphorylation
GO:0043988	histone H3-S28 phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070498	interleukin-1-mediated signaling pathway