InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EPHA4

Summary

InnateDB Protein

IDBP-696760.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EPHA4

Protein Name

ephrin receptor EphA4

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013238

InnateDB Gene

IDBG-644137 (EPHA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005004	GPI-linked ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042731	PH domain binding
GO:0042802	identical protein binding
GO:0097161	DH domain binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007628	adult walking behavior
GO:0008045	motor neuron axon guidance
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021957	corticospinal tract morphogenesis
GO:0032314	regulation of Rac GTPase activity
GO:0032317	regulation of Rap GTPase activity
GO:0043507	positive regulation of JUN kinase activity
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0048681	negative regulation of axon regeneration
GO:0048710	regulation of astrocyte differentiation
GO:0050770	regulation of axonogenesis
GO:0061001	regulation of dendritic spine morphogenesis
GO:0097155	fasciculation of sensory neuron axon
GO:0097156	fasciculation of motor neuron axon
GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00069
PF01404
PF07714
PF00041
PF01108
PF07647
PF00536

PRINTS

PR00109

PIRSF

PIRSF000666

SMART

SM00615
SM00454
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BER5

UniProt Splice Variant

Entrez Gene

520192

UniGene

Bt.103517

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02005982 DAAA02005983 DAAA02005984 DAAA02005985

GenPept