Version 5.4
Bos taurus Protein: CDC42EP2
Summary
InnateDB Protein IDBP-696784.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP2
Protein Name Cdc42 effector protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042899
InnateDB Gene IDBG-644168 (CDC42EP2)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). {ECO:0000250}.
Subcellular Localization Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0032321 positive regulation of Rho GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
IPR017363 Cdc42 effector protein 2
PFAM PF00786
PRINTS
PIRSF PIRSF038036
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DN6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507966
UniGene Bt.52103
RefSeq NP_001068809
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123647
GenPept AAI23648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca