InnateDB Protein
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IDBP-696867.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CFL1
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Protein Name
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Cofilin-1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000028602
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InnateDB Gene
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IDBG-644243 (CFL1)
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Protein Structure
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Function |
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Required for the up- regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
53 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002108
Actin-depolymerising factor homology domain
IPR017904
ADF/Cofilin/Destrin
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PFAM |
PF00241
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PRINTS |
PR00006
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PIRSF |
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SMART |
SM00102
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TIGRFAMs |
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Modification |
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SwissProt |
Q5E9F7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B0JYL8
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UniProt Splice Variant |
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Entrez Gene |
534553
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UniGene |
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RefSeq |
NP_001015655
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC103077
BC151403
BT020963
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GenPept |
AAI03078
AAI51404
AAX08980
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