Version 5.4
Bos taurus Gene: CFL1
Summary
InnateDB Gene IDBG-644243.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CFL1
Gene Name Cofilin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021455
Encoded Proteins
IDBP-696867
Cofilin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172757:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:44638896-44642280
Strand Reverse strand
Band
Transcripts
ENSBTAT00000028602 ENSBTAP00000028602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0001755 neural crest cell migration
GO:0001842 neural fold formation
GO:0006468 protein phosphorylation
GO:0006928 cellular component movement
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0009615 response to virus
GO:0022604 regulation of cell morphogenesis
GO:0030010 establishment of cell polarity
GO:0030042 actin filament depolymerization
GO:0030836 positive regulation of actin filament depolymerization
GO:0043200 response to amino acid
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030864 cortical actin cytoskeleton
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000172757
View Gene Order
ENSMUSG00000056201
View Gene Order
Pathways
NETPATH
REACTOME
REACT_202252
Platelet degranulation pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_212196
Hemostasis pathway
REACT_213138
Immune System pathway
REACT_209572
Platelet activation, signaling and aggregation pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_212308
Response to elevated platelet cytosolic Ca2+ pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_203140
Axon guidance pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_221457
Semaphorin interactions pathway
REACT_220844
Developmental Biology pathway
REACT_205196
Sema3A PAK dependent Axon repulsion pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_604
Hemostasis pathway
REACT_230203
Platelet degranulation pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_224553
Hemostasis pathway
REACT_254306
Sema3A PAK dependent Axon repulsion pathway
REACT_230745
Immune System pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04360
Axon guidance pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
mmu04360
Axon guidance pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
INOH
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
rac1_pathway
RAC1 signaling pathway
cdc42_pathway
CDC42 signaling events
rhoa_pathway
RhoA signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001015655 XM_005227121
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca