Version 5.4
Bos taurus Protein: BRMS1
Summary
InnateDB Protein IDBP-697017.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRMS1
Protein Name Breast cancer metastasis-suppressor 1 homolog
Synonyms BRMS1L;
Species Bos taurus
Ensembl Protein ENSBTAP00000023526
InnateDB Gene IDBG-644383 (BRMS1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0009987 cellular process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090312 positive regulation of protein deacetylation
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR013907 Sds3-like
PFAM PF08598
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1LZE0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615952
UniGene Bt.28488
RefSeq NP_001069872
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116061
GenPept AAI16062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca