InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RGS20

Summary

InnateDB Protein

IDBP-697040.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS20

Protein Name

Regulator of G-protein signaling 20

Synonyms

RSG20;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004487

InnateDB Gene

IDBG-644406 (RGS20)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Retinal-specific. Expressed throughout the retina, including photoreceptors.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0009968	negative regulation of signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615

PRINTS

PR01301

PIRSF

SMART

SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P79348

PhosphoSite

PhosphoSite-

TrEMBL

Q1LZG3

UniProt Splice Variant

Entrez Gene

614441

UniGene

Bt.47430

RefSeq

XP_005215480

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116015 DAAA02038289 U89254

GenPept

AAC48721 AAI16016