Version 5.4
Bos taurus Protein: NPPC
Summary
InnateDB Protein IDBP-697091.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPPC
Protein Name C-type natriuretic peptideCNP-22CNP-29CNP-53
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055472
InnateDB Gene IDBG-644450 (NPPC)
Protein Structure
UniProt Annotation
Function Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001503 ossification
GO:0003418 growth plate cartilage chondrocyte differentiation
GO:0003419 growth plate cartilage chondrocyte proliferation
GO:0006182 cGMP biosynthetic process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0050880 regulation of blood vessel size
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000663 Natriuretic peptide
IPR002406 Natriuretic peptide, C type
IPR002407 Natriuretic peptide, atrial type
IPR002408 Natriuretic peptide, brain type
PFAM PF00212
PRINTS PR00710
PR00713
PR00711
PR00712
PIRSF
SMART SM00183
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55206
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281356
UniGene Bt.4102
RefSeq XP_005202941
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123399 Z48477 Z48478
GenPept AAI23400 CAA88368 CAA88369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca