Version 5.4
Bos taurus Protein: PTPN2
Summary
InnateDB Protein IDBP-697131.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPN2
Protein Name tyrosine-protein phosphatase non-receptor type 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013969
InnateDB Gene IDBG-644489 (PTPN2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010888 negative regulation of lipid storage
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042512 negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein
GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein
GO:0042593 glucose homeostasis
GO:0045650 negative regulation of macrophage differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050922 negative regulation of chemotaxis
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0070104 negative regulation of interleukin-6-mediated signaling pathway
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway
GO:1902206 negative regulation of interleukin-2-mediated signaling pathway
GO:1902212 negative regulation of prolactin signaling pathway
GO:1902215 negative regulation of interleukin-4-mediated signaling pathway
GO:1902227 negative regulation of macrophage colony-stimulating factor signaling pathway
GO:1902233 negative regulation of positive thymic T cell selection
GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PRINTS PR00700
PIRSF PIRSF000926
SMART SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5D982
UniProt Splice Variant
Entrez Gene 540888
UniGene Bt.24652
RefSeq NP_001030508
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT030501 DAAA02056846
GenPept ABQ12941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca