|Bos taurus Gene: PTPN2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||tyrosine-protein phosphatase non-receptor type 2|
tyrosine-protein phosphatase non-receptor type 2
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Homo sapiens] PTPN2 pays a novel role in the regulation of type 1 interferon-stimulated gene expression in cells previously desensitized to Type 1 interferons.
[Homo sapiens] PTPN2 is a nuclear protein tyrosine phosphatase, a potential negative regulator of the PRL-mediated signalling pathway.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175354:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
|Genomic Location||Chromosome 24:43539648-43607714|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
Cytokine Signaling in Immune system pathway
Immune System pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2
PDGFR-beta signaling pathway
|UniProt Splice Variant|
|RNA Seq Atlas||540888|