Version 5.4
Bos taurus Protein: SEH1L
Summary
InnateDB Protein IDBP-697135.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEH1L
Protein Name Nucleoporin SEH1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045994
InnateDB Gene IDBG-644494 (SEH1L)
Protein Structure
UniProt Annotation
Function Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (By similarity). As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway (By similarity). {ECO:0000250}.
Subcellular Localization Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002534 cytokine production involved in inflammatory response
GO:0006810 transport
GO:0006999 nuclear pore organization
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0015031 protein transport
GO:0050830 defense response to Gram-positive bacterium
GO:0051028 mRNA transport
GO:0051301 cell division
GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005694 chromosome
GO:0031080 nuclear pore outer ring
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7YY75
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506509
UniGene Bt.71586
RefSeq NP_001096559
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151606
GenPept AAI51607

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca