InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LCK

Summary

InnateDB Protein

IDBP-697241.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LCK

Protein Name

lymphocyte-specific protein tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000037887

InnateDB Gene

IDBG-644592 (LCK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 108 interaction(s) predicted by orthology.

Predicted by orthology
Total	108 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001948	glycoprotein binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0042169	SH2 domain binding
GO:0042609	CD4 receptor binding
GO:0042610	CD8 receptor binding
GO:0042802	identical protein binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0051117	ATPase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006882	cellular zinc ion homeostasis
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0016310	phosphorylation
GO:0016311	dephosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030217	T cell differentiation
GO:0042493	response to drug
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0046777	protein autophosphorylation
GO:0050853	B cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051209	release of sequestered calcium ion into cytosol
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000242	pericentriolar material
GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00017
PF14633
PF07714
PF00018
PF14604
PF07653

PRINTS

PR00401
PR00109
PR00452

PIRSF

SMART

SM00252
SM00326
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3ZCM0

UniProt Splice Variant

Entrez Gene

508890

UniGene

Bt.49263

RefSeq

NP_001029506

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102046 DAAA02006244

GenPept

AAI02047