Version 5.4
| Bos taurus Gene: LCK | |||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-644592.3 | ||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | LCK | ||||||||||||||||||||||||||||||||||||||||
| Gene Name | tyrosine-protein kinase Lck | ||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000012695 | ||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
lymphocyte-specific protein tyrosine kinase
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182866:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 2:122092889-122113823 | ||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 108 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Notch pathway
EGFR1 pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
Leptin pathway
TSLP pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Interleukin-2 signaling pathway
CTLA4 inhibitory signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
PECAM1 interactions pathway
Cell surface interactions at the vascular wall pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Nef and signal transduction pathway
Nef Mediated CD4 Down-regulation pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
TCR signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
NGF signalling via TRKA from the plasma membrane pathway
HIV Infection pathway
PI3K/AKT Signaling in Cancer pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
PD-1 signaling pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Hemostasis pathway
Interleukin-2 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Regulation of KIT signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Translocation of ZAP-70 to Immunological synapse pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
CTLA4 inhibitory signaling pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Generation of second messenger molecules pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Primary immunodeficiency pathway
Osteoclast differentiation pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Primary immunodeficiency pathway
Osteoclast differentiation pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
Atypical NF-kappaB pathway
TCR signaling in naïve CD8+ T cells
IL2-mediated signaling events
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
IL12-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||
| TrEMBL | Q3ZCM0 | ||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 508890 | ||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.49263 | ||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001034334 | ||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||
| EMBL | BC102046 DAAA02006244 | ||||||||||||||||||||||||||||||||||||||||
| GenPept | AAI02047 | ||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 508890 | ||||||||||||||||||||||||||||||||||||||||