Version 5.4
Bos taurus Protein: CCND1
Summary
InnateDB Protein IDBP-697691.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND1
Protein Name G1/S-specific cyclin-D1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023277
InnateDB Gene IDBG-645012 (CCND1)
Protein Structure
UniProt Annotation
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 132 interaction(s) predicted by orthology.
Predicted by orthology
Total 132 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042826 histone deacetylase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000320 re-entry into mitotic cell cycle
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007595 lactation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0033598 mammary gland epithelial cell proliferation
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0042493 response to drug
GO:0045444 fat cell differentiation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060070 canonical Wnt signaling pathway
GO:0060749 mammary gland alveolus development
GO:0070141 response to UV-A
GO:0071157 negative regulation of cell cycle arrest
GO:0071310 cellular response to organic substance
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005923 tight junction
GO:0016020 membrane
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID
InterPro IPR004367 Cyclin, C-terminal domain
IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
IPR014400 Cyclin A/B/D/E/F
PFAM PF02984
PF00134
PRINTS
PIRSF PIRSF001771
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KI22
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 524530
UniGene Bt.88783
RefSeq NP_001039738
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112798
GenPept AAI12799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca