Version 5.4
Bos taurus Gene: CCND1
Summary
InnateDB Gene IDBG-645012.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND1
Gene Name G1/S-specific cyclin-D1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017514
Encoded Proteins
IDBP-697691
G1/S-specific cyclin-D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110092:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:47544380-47553820
Strand Forward strand
Band
Transcripts
ENSBTAT00000023277 ENSBTAP00000023277
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 132 interaction(s) predicted by orthology.
Predicted by orthology
Total 132 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042826 histone deacetylase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000320 re-entry into mitotic cell cycle
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007595 lactation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0033598 mammary gland epithelial cell proliferation
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0042493 response to drug
GO:0045444 fat cell differentiation
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060070 canonical Wnt signaling pathway
GO:0060749 mammary gland alveolus development
GO:0070141 response to UV-A
GO:0071157 negative regulation of cell cycle arrest
GO:0071310 cellular response to organic substance
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005923 tight junction
GO:0016020 membrane
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000110092
View Gene Order
ENSMUSG00000070348
View Gene Order
Pathways
NETPATH
REACTOME
REACT_225014
S Phase pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_218138
Cyclin D associated events in G1 pathway
REACT_210825
G1 Phase pathway
REACT_207632
Chromatin organization pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_212546
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_214934
Cell Cycle pathway
REACT_243659
RMTs methylate histone arginines pathway
REACT_218058
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_4
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_1590
G1 Phase pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_111102
Signal Transduction pathway
REACT_938
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_115566
Cell Cycle pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_218274
Chromatin organization pathway
REACT_260005
G1 Phase pathway
REACT_263467
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_196494
Pre-NOTCH Expression and Processing pathway
REACT_268602
Pre-NOTCH Transcription and Translation pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_247652
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_244207
RMTs methylate histone arginines pathway
REACT_188257
Signal Transduction pathway
REACT_231152
Signaling by NOTCH pathway
REACT_253623
S Phase pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05210
Colorectal cancer pathway
hsa05223
Non-small cell lung cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05216
Thyroid cancer pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
mmu05213
Endometrial cancer pathway
mmu05219
Bladder cancer pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04115
p53 signaling pathway pathway
mmu05221
Acute myeloid leukemia pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu05216
Thyroid cancer pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
mmu05416
Viral myocarditis pathway
INOH
PID NCI
pi3kplctrkpathway
Trk receptor signaling mediated by PI3K and PLC-gamma
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
ar_pathway
Coregulation of Androgen receptor activity
ps1pathway
Presenilin action in Notch and Wnt signaling
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
atf2_pathway
ATF-2 transcription factor network
fak_pathway
Signaling events mediated by focal adhesion kinase
myc_represspathway
Validated targets of C-MYC transcriptional repression
betacatenin_nuc_pathway
Regulation of nuclear beta catenin signaling and target gene transcription
ilk_pathway
Integrin-linked kinase signaling
ap1_pathway
AP-1 transcription factor network
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
cmyb_pathway
C-MYB transcription factor network
foxm1pathway
FOXM1 transcription factor network
telomerasepathway
Regulation of Telomerase
notch_pathway
Notch signaling pathway
Cross-References
SwissProt Q2KI22
TrEMBL
UniProt Splice Variant
Entrez Gene 524530
UniGene Bt.88783
RefSeq NM_001046273
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112798
GenPept AAI12799
RNA Seq Atlas 524530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca