Version 5.4
Bos taurus Protein: YWHAZ
Summary
InnateDB Protein IDBP-697786.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAZ
Protein Name 14-3-3 protein zeta/delta
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000289
InnateDB Gene IDBG-645101 (YWHAZ)
Protein Structure
UniProt Annotation
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. {ECO:0000269PubMed:7931346}.
Subcellular Localization Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 644 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 644 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000308 14-3-3 protein
IPR023410 14-3-3 domain
PFAM PF00244
PRINTS PR00305
PIRSF PIRSF000868
SMART SM00101
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P63103
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 287022
UniGene Bt.91635
RefSeq NP_777239
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102382 L07955
GenPept AAA30514 AAI02383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca