Version 5.4
| Bos taurus Gene: YWHAZ | |||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-645101.3 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | YWHAZ | ||||||||||||||||||||||
| Gene Name | 14-3-3 protein zeta/delta | ||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000000236 | ||||||||||||||||||||||
| Encoded Proteins |
14-3-3 protein zeta/delta
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164924:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5\' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008] |
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| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 14:65584487-65617329 | ||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||
| Band | |||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 644 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
KSRP destabilizes mRNA pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
TCF dependent signaling in response to WNT pathway
Activation of BH3-only proteins pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Cytokine Signaling in Immune system pathway
deactivation of the beta-catenin transactivating complex pathway
Translocation of GLUT4 to the plasma membrane pathway
Gene Expression pathway
Hemostasis pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Signal Transduction pathway
Intrinsic Pathway for Apoptosis pathway
GP1b-IX-V activation signalling pathway
Adaptive Immune System pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Activation of BAD and translocation to mitochondria pathway
Rap1 signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by Interleukins pathway
Disease pathway
Apoptosis pathway
Membrane Trafficking pathway
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| KEGG | |||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
TNFalpha pathway
TCR pathway
IL3 pathway
IL5 pathway
Prolactin pathway
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| REACTOME |
Rap1 signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
GP1b-IX-V activation signalling pathway
KSRP destabilizes mRNA pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Cytokine Signaling in Immune system pathway
Platelet activation, signaling and aggregation pathway
deactivation of the beta-catenin transactivating complex pathway
Apoptosis pathway
Signal Transduction pathway
Adaptive Immune System pathway
Activation of BH3-only proteins pathway
Immune System pathway
TCF dependent signaling in response to WNT pathway
Signaling by Interleukins pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Intrinsic Pathway for Apoptosis pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Gene Expression pathway
Disease pathway
Hemostasis pathway
Membrane Trafficking pathway
GP1b-IX-V activation signalling pathway
Apoptosis pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
Membrane Trafficking pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Cytokine Signaling in Immune system pathway
KSRP destabilizes mRNA pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
deactivation of the beta-catenin transactivating complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Activation of BAD and translocation to mitochondria pathway
TCF dependent signaling in response to WNT pathway
Rap1 signalling pathway
Signaling by Interleukins pathway
Gene Expression pathway
Activation of BH3-only proteins pathway
Adaptive Immune System pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Translocation of GLUT4 to the plasma membrane pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Intrinsic Pathway for Apoptosis pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Cell cycle pathway
Oocyte meiosis pathway
Cell cycle pathway
Oocyte meiosis pathway
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| INOH |
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
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| PID NCI |
Class I PI3K signaling events mediated by Akt
ErbB1 downstream signaling
IGF1 pathway
IL3-mediated signaling events
Alpha4 beta1 integrin signaling events
GMCSF-mediated signaling events
ATR signaling pathway
p38 signaling mediated by MAPKAP kinases
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| Cross-References | |||||||||||||||||||||||
| SwissProt | P63103 | ||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 287022 | ||||||||||||||||||||||
| UniGene | Bt.91635 | ||||||||||||||||||||||
| RefSeq | NM_174814 XM_005215615 | ||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | BC102382 L07955 | ||||||||||||||||||||||
| GenPept | AAA30514 AAI02383 | ||||||||||||||||||||||
| RNA Seq Atlas | 287022 | ||||||||||||||||||||||