Version 5.4
Bos taurus Protein: TNNC1
Summary
InnateDB Protein IDBP-698307.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNC1
Protein Name Troponin C, slow skeletal and cardiac muscles
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055780
InnateDB Gene IDBG-645587 (TNNC1)
Protein Structure
UniProt Annotation
Function Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0031013 troponin I binding
GO:0031014 troponin T binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Biological Process
GO:0006937 regulation of muscle contraction
GO:0032972 regulation of muscle filament sliding speed
GO:0043462 regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005861 troponin complex
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P63315
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509486
UniGene Bt.49083
RefSeq NP_001029523
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102995
GenPept AAI02996

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca