Version 5.4
Bos taurus Protein: VDAC1
Summary
InnateDB Protein IDBP-698528.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC1
Protein Name Voltage-dependent anion-selective channel protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017430
InnateDB Gene IDBG-645740 (VDAC1)
Protein Structure
UniProt Annotation
Function Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Subcellular Localization Mitochondrion outer membrane. Cell membrane.
Disease Associations
Tissue Specificity Predominantly in brain astrocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006915 apoptotic process
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0046930 pore complex
Protein Structure and Domains
PDB ID
InterPro IPR001925 Porin, eukaryotic type
IPR027246 Eukaryotic porin/Tom40
PFAM PF01459
PRINTS PR00185
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P45879
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282119
UniGene Bt.92399
RefSeq NP_776910
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF268464 BC102113 X75068
GenPept AAF80101 AAI02114 CAA52962

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca