InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRMT5

Summary

InnateDB Protein

IDBP-698627.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT5

Protein Name

protein arginine N-methyltransferase 5

Synonyms

SKB1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014463

InnateDB Gene

IDBG-645872 (PRMT5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 96 interaction(s) predicted by orthology.

Predicted by orthology
Total	96 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000387	spliceosomal snRNP assembly
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0018216	peptidyl-arginine methylation
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0032259	methylation
GO:0034969	histone arginine methylation
GO:0035246	peptidyl-arginine N-methylation
GO:0042118	endothelial cell activation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034709	methylosome

Protein Structure and Domains

PDB ID

InterPro

IPR007857 Protein arginine N-methyltransferase PRMT5
IPR025799 Protein arginine N-methyltransferase
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05185

PRINTS

PIRSF

PIRSF015894

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite