InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GATM

Summary

InnateDB Protein

IDBP-699519.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GATM

Protein Name

Glycine amidinotransferase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007338

InnateDB Gene

IDBG-646693 (GATM)

Protein Structure

UniProt Annotation

Function

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015068	glycine amidinotransferase activity
GO:0016740	transferase activity
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0006601

creatine biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome