InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LGALS3

Summary

InnateDB Protein

IDBP-699545.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS3

Protein Name

galectin-3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041298

InnateDB Gene

IDBG-646716 (LGALS3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0042056	chemoattractant activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002548	monocyte chemotaxis
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0030855	epithelial cell differentiation
GO:0042129	regulation of T cell proliferation
GO:0045806	negative regulation of endocytosis
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0050918	positive chemotaxis
GO:0070232	regulation of T cell apoptotic process
GO:0071674	mononuclear cell migration
GO:0071677	positive regulation of mononuclear cell migration
GO:0090280	positive regulation of calcium ion import
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00337

PRINTS

PIRSF

SMART

SM00276
SM00908

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A6QLZ0

UniProt Splice Variant

Entrez Gene

786492

UniGene

RefSeq

NP_001095811

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC148136 DAAA02029206 DAAA02029207

GenPept

AAI48137