|Bos taurus Gene: LGALS3|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Useful resources||Stemformatics EHFPI ImmGen|
|InnateDB Annotation from Orthologs|
[Homo sapiens] LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.
[Homo sapiens] LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.
[Homo sapiens] LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
[Homo sapiens] LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)
[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
[Mus musculus] Lgals3 influences the course of malaria in a Plasmodium species-specific manner.
[Mus musculus] Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131981:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
|Genomic Location||Chromosome 10:67843328-67861113|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
Innate Immune System pathway
Immune System pathway
Advanced glycosylation endproduct receptor signaling pathway
Regulation of Ras family activation
Hedgehog signaling events mediated by Gli proteins
|UniProt Splice Variant|
|EMBL||BC148136 DAAA02029206 DAAA02029207|
|RNA Seq Atlas||786492|