Version 5.4
Bos taurus Gene: LGALS3
Summary
InnateDB Gene IDBG-646716.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS3
Gene Name galectin-3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002326
Encoded Proteins
IDBP-699545
galectin-3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18825751
[Homo sapiens] LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.
PMID 19951367
[Homo sapiens] LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.
PMID 20208507
[Homo sapiens] LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.
PMID 22486577
[Homo sapiens] LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)
PMID 26589797
[Homo sapiens] LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.
PMID 22486577
[Mus musculus] Lgals3 influences the course of malaria in a Plasmodium species-specific manner.
PMID 26857579
[Mus musculus] Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131981:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:67843328-67861113
Strand Forward strand
Band
Transcripts
ENSBTAT00000043753 ENSBTAP00000041298
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
Predicted by orthology
Total 64 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019863 IgE binding
GO:0030246 carbohydrate binding
GO:0042056 chemoattractant activity
GO:0043236 laminin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001501 skeletal system development
GO:0002548 monocyte chemotaxis
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0030855 epithelial cell differentiation
GO:0042129 regulation of T cell proliferation
GO:0045806 negative regulation of endocytosis
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0050918 positive chemotaxis
GO:0070232 regulation of T cell apoptotic process
GO:0071674 mononuclear cell migration
GO:0071677 positive regulation of mononuclear cell migration
GO:0090280 positive regulation of calcium ion import
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000131981
View Gene Order
ENSMUSG00000050335
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL A6QLZ0
UniProt Splice Variant
Entrez Gene 786492
UniGene
RefSeq NM_001102341
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC148136 DAAA02029206 DAAA02029207
GenPept AAI48137
RNA Seq Atlas 786492

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca