Bos taurus Protein: SNW1
InnateDB Protein IDBP-699749.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNW1
Protein Name SNW domain-containing protein 1
Synonyms NCOA-62; SKIIP;
Species Bos taurus
Ensembl Protein ENSBTAP00000010697
InnateDB Gene IDBG-646903 (SNW1)
Protein Structure
UniProt Annotation
Function Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Functions as a splicing factor in pre-mRNA splicing. Is required in the specific splicing of CDKN1A pre-mRNA; the function probbaly involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 118 interaction(s) predicted by orthology.
Predicted by orthology
Total 118 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0035257 nuclear hormone receptor binding
GO:0042809 vitamin D receptor binding
GO:0042974 retinoic acid receptor binding
GO:0044822 poly(A) RNA binding
GO:0046332 SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000398 mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0008380 RNA splicing
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043923 positive regulation by host of viral transcription
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0048384 retinoic acid receptor signaling pathway
GO:0048385 regulation of retinoic acid receptor signaling pathway
GO:0050769 positive regulation of neurogenesis
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0070564 positive regulation of vitamin D receptor signaling pathway
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0008024 positive transcription elongation factor complex b
GO:0016363 nuclear matrix
GO:0071013 catalytic step 2 spliceosome
GO:0071146 SMAD3-SMAD4 protein complex
Protein Structure and Domains
InterPro IPR004015 SKI-interacting protein SKIP, SNW domain
IPR013822 Signal recognition particle, SRP54 subunit, helical bundle
PFAM PF02731
Post-translational Modifications
SwissProt Q1JQE0
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 326578
UniGene Bt.42459
RefSeq NP_001071302
EMBL BC116009
GenPept AAI16010