InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: B2M

Summary

InnateDB Protein

IDBP-699790.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B2M

Protein Name

Beta-2-microglobulin

Synonyms

B2M;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016359

InnateDB Gene

IDBG-646936 (B2M)

Protein Structure

UniProt Annotation

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002376	immune system process
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0033077	T cell differentiation in thymus
GO:0042026	protein refolding

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0042612	MHC class I protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain

PFAM

PF07654

PRINTS

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01888

PhosphoSite

PhosphoSite-

TrEMBL

Q862Q3

UniProt Splice Variant

Entrez Gene

783680

UniGene

RefSeq

NP_776318

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB098926 AY325772 AY911322 BC118352 X69084

GenPept

AAI18353 AAP78964 AAW82090 BAC56416 CAA48828